Source: | Rabbit | Gene Id: | 80196 |
Isotype: | IgG | Swiss Prot: | Q969K3 |
purity: | Affinity purification |
Background: |
The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. This protein also targets p53 and phospho-p53 for degradation. Alternatively splicing results in multiple transcript variants encoding distinct isoforms. |
Reactivity | Human |
Tested applications | WB |
Clonality | Polyclonal Antibody |
Calculated MW | 42kDa |
Recommended Dilutions |
WB 1:500-1:2000
|
Immunogen | Recombinant protein of human RNF34 |
Storage | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Synonym | RFI, RIF, RIFF, hRFI, CARP1, CARP-1 |
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