PTPRC Rabbit Polyclonal Antibody
No Size Price Availability  
ARP5788-01 50ul 1500.00 In Stock
ARP5788-01 100ul 2000.00 In Stock
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Source: Rabbit Gene Id: 5788
Isotype: IgG Swiss Prot: P08575
purity: Affinity purification
Background:
The protein phosphatase (PTP) receptor CD45 is a type I transmembrane protein comprised of a pair of intracellular tyrosine phosphatase domains and a variable extracellular domain generated by alternative splicing (1). The catalytic activity of CD45 is a function of the first phosphatase domain (D1) while the second phosphatase domain (D2) may interact with and stabilize the first domain, or recruit/bind substrates (2,3). CD45 interacts directly with antigen receptor complex proteins or activates Src family kinases involved in the regulation of T- and B-cell antigen receptor signaling (1). Specifically, CD45 dephosphorylates Src-family kinases Lck and Fyn at their conserved negative regulatory carboxy-terminal tyrosine residues and upregulates kinase activity. Conversely, studies indicate that CD45 can also inhibit Lck and Fyn by dephosphorylating their positive regulatory autophosphorylation site. CD45 appears to be both a positive and a negative regulator that conducts signals depending on specific stimuli and cell type (1). Human leukocytes including lymphocytes, eosinophils, monocytes, basophils and neutrophils express CD45, while erythrocytes and platelets are negative for CD45 expression (4).
Reactivity Human, Mouse
Tested applications WB
Clonality Polyclonal Antibody
Calculated MW 147kDa
Recommended Dilutions
WB 1:500-1:2000
Immunogen A synthetic peptide of human PTPRC
Storage Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Synonym B220, CD45, CD45R, GP180, LCA, LY5, T200
This product is for research use only, not for diagnostic or therapeutic use!

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