Source: | Rabbit | Gene Id: | 1493 |
Isotype: | IgG | Swiss Prot: | P16410 |
purity: | Affinity purification |
Background: |
This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008] |
Reactivity | Human, Mouse |
Tested applications | WB |
Clonality | Polyclonal Antibody |
Calculated MW | 25kDa |
Recommended Dilutions |
WB 1:500-1:2000
|
Immunogen | A synthetic peptide of human AKT1 |
Storage | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Synonym | CTLA4;CD;CD152;CELIAC3;CTLA-4;GRD4;GSE;ICOS;IDDM12 |
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