| No | Size | Price | Availability | |
| ARP1244-01 | 50ul | 1500.00 | In Stock |  |
| ARP1244-01 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 1244 |
| Isotype: | IgG | Swiss Prot: | Q92887 |
| purity: | Affinity purification |
| Background: |
| The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. |
| Reactivity | Human |
| Tested applications | WB |
| Clonality | Polyclonal Antibody |
| Calculated MW | 174kDa |
| Recommended Dilutions |
WB 1:500-1:2000
|
| Immunogen | Recombinant protein of human ABCC2 |
| Storage | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Synonym | DJS, MRP2, cMRP, ABC30, CMOAT |
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