CHM Rabbit Polyclonal Antibody
No Size Price Availability  
ARP1121-01 50ul 1500.00 In Stock
ARP1121-01 100ul 2000.00 In Stock
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Source: Rabbit Gene Id: 1121
Isotype: IgG Swiss Prot: P24386
purity: Affinity purification
Background:
This gene encodes component A of the RAB geranylgeranyl transferase holoenzyme. In the dimeric holoenzyme, this subunit binds unprenylated Rab GTPases and then presents them to the catalytic Rab GGTase subunit for the geranylgeranyl transfer reaction. Rab GTPases need to be geranylgeranyled on either one or two cysteine residues in their C-terminus to localize to the correct intracellular membrane. Mutations in this gene are a cause of choroideremia; also known as tapetochoroidal dystrophy (TCD). This X-linked disease is characterized by progressive dystrophy of the choroid, retinal pigment epithelium and retina. Alternative splicing results in multiple transcript variants encoding different isoforms.
Reactivity Human
Tested applications WB
Clonality Polyclonal Antibody
Calculated MW 73kDa
Recommended Dilutions
WB 1:500-1:2000
Immunogen Recombinant protein of human CHM
Storage Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Synonym TCD, GGTA, REP-1, DXS540, HSD-32
This product is for research use only, not for diagnostic or therapeutic use!

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