| No | Size | Price | Availability | |
| YRP01234-01 | 50ul | 1500.00 | In Stock |  |
| YRP01234-01 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 26574 |
| Isotype: | IgG | Swiss Prot: | Q9NY61 |
| purity: | Purified by Protein A. |
| Background: |
| May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date. |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB IHC IF |
| Clonality | Polyclonal Antibody |
| Calculated MW | / |
| Recommended Dilutions |
WB 1:100-1:1000
IHC 1:100-1:500
IF 1:50-1:200
|
| Immunogen | KLH conjugated synthetic peptide derived from human AATF |
| Storage | Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at -20℃ for 12 months |
| Synonym | DED, BFR2, CHE1, CHE-1, Protein AATF, Apoptosis-antagonizing transcription factor, Rb-binding protein Che-1, AATF, HSPC277 |
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