PTTG1 Rabbit Polyclonal Antibody
No Size Price Availability  
ARP9232-01 50ul 1500.00 In Stock
ARP9232-01 100ul 2000.00 In Stock
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Source: Rabbit Gene Id: 9232
Isotype: IgG Swiss Prot: O95997
purity: Affinity purification
Background:
The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]
Reactivity Human, Mouse, Rat
Tested applications WB
Clonality Polyclonal Antibody
Calculated MW 22 kDa
Recommended Dilutions
WB 1:500-1:2000
Immunogen Recombinant protein of human PTTG1
Storage Store at -20°C (regular) or -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Synonym
This product is for research use only, not for diagnostic or therapeutic use!

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