BRCC3 Rabbit Polyclonal Antibody
No Size Price Availability  
ARP79184-01 50ul 1500.00 In Stock
ARP79184-01 100ul 2000.00 In Stock
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Source: Rabbit Gene Id: 79184
Isotype: IgG Swiss Prot: P46736
purity: Affinity purification
Background:
This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jun 2011]
Reactivity Human, Mouse, Rat
Tested applications WB IHC
Clonality Polyclonal Antibody
Calculated MW 36 kDa
Recommended Dilutions
WB 1:500-1:2000
IHC 1:50-1:200
Immunogen Recombinant protein of human BRCC3
Storage Store at -20°C (regular) or -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Synonym C6.1A, BRCC36, CXorf53
This product is for research use only, not for diagnostic or therapeutic use!

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