UGDH Rabbit Polyclonal Antibody
No Size Price Availability  
ARP7358-01 50ul 1500.00 In Stock
ARP7358-01 100ul 2000.00 In Stock
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Source: Rabbit Gene Id: 7358
Isotype: IgG Swiss Prot: O60701
purity: Affinity purification
Background:
UDP-GlcDH (also called UDP-glucose 6-dehydrogenase, UGDH or UDPGDH) is a member of the UDP-glucose/GDP-mannose dehydrogenase family. UDP-GlcDH converts UDP-glucose to UDP-glucuronic acid, which is a crucial component in the biosynthesis of the glycosaminoglycans, hyaluronan, heparan sulfate and chondroitin sulfate. Found as common components of the extracellular matrix, these glycosaminoglycans are significant in signal transduction, cell migration, cancer growth and cancer metastasis. UDP-glucuronic acid (UDP-GlcA) is needed in the liver for the excretion of toxic compounds. UDP-GlcDH is a ubiquitously expressed protein most abundant in the liver. The protein structure of UDP-GlcDH was first analyzed in cow liver and found to be a homohexamer. This structure is well conserved between species and phyla with an overall 97% sequence identity shared between different species of mammals. Research indicates that UDP-GlcDH expression is upregulated by TGF∫ and downregulated by hypoxia.
Reactivity Human, Mouse, Rat
Tested applications WB IHC IF
Clonality Polyclonal Antibody
Calculated MW 55 kDa
Recommended Dilutions
WB 1:500-1:2000
IHC 1:50-1:200
IF 1:50-1:200
Immunogen Recombinant protein of human UGDH
Storage Store at -20°C (regular) or -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Synonym GDH, UGD, UDPGDH, UDP-GlcDH
This product is for research use only, not for diagnostic or therapeutic use!

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