FBXW4 Rabbit Polyclonal Antibody
No Size Price Availability  
ARP6468-01 50ul 1500.00 In Stock
ARP6468-01 100ul 2000.00 In Stock
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Source: Rabbit Gene Id: 6468
Isotype: IgG Swiss Prot: P57775
purity: Affinity purification
Background:
This gene is a member of the F-box/WD-40 gene family, which recruit specific target proteins through their WD-40 protein-protein binding domains for ubiquitin mediated degradation. In mouse, a highly similar protein is thought to be responsible for maintaining the apical ectodermal ridge of developing limb buds; disruption of the mouse gene results in the absence of central digits, underdeveloped or absent metacarpal/metatarsal bones and syndactyly. This phenotype is remarkably similar to split hand-split foot malformation in humans, a clinically heterogeneous condition with a variety of modes of transmission. An autosomal recessive form has been mapped to the chromosomal region where this gene is located, and complex rearrangements involving duplications of this gene and others have been associated with the condition. A pseudogene of this locus has been mapped to one of the introns of the BCR gene on chromosome 22. [provided by RefSeq, Jul 2008]
Reactivity Human, Mouse
Tested applications WB
Clonality Polyclonal Antibody
Calculated MW 46 kDa
Recommended Dilutions
WB 1:500-1:2000
Immunogen Recombinant protein of human FBXW4
Storage Store at -20°C (regular) or -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Synonym DAC, FBW4, FBWD4, SHFM3, SHSF3
This product is for research use only, not for diagnostic or therapeutic use!

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