MAP2K3 Rabbit Polyclonal Antibody
No Size Price Availability  
ARP5606-01 50ul 1500.00 In Stock
ARP5606-01 100ul 2000.00 In Stock
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Source: Rabbit Gene Id: 5606
Isotype: IgG Swiss Prot: P46734
purity: Affinity purification
Background:
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene.
Reactivity Human, Mouse, Rat
Tested applications WB IHC
Clonality Polyclonal Antibody
Calculated MW 39 kDa
Recommended Dilutions
WB 1:500-1:2000
IHC 1:50-1:200
Immunogen Recombinant protein of human MAP2K3
Storage Store at -20°C (regular) or -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Synonym MEK3, MKK3, MAPKK3, PRKMK3, SAPKK2, SAPKK-2
This product is for research use only, not for diagnostic or therapeutic use!

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