Phospho-ERK3-S189 Rabbit Polyclonal Antibody
No Size Price Availability  
ARP5597P-01 50ul 1500.00 In Stock
ARP5597P-01 100ul 2000.00 In Stock
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Source: Rabbit Gene Id: 5597
Isotype: IgG Swiss Prot: Q16659
purity: Affinity purification
Background:
Erk3, also known as MAPK6 or p97 MAPK, is almost 50% identical to Erk1/2 at the kinase domain located in its amino-terminal region (1). However, Erk3 is distinguished from other MAP kinases in that it lacks the conserved TXY motif in its activation loop, possessing instead an SEG motif (1,2). Phosphorylation at Ser189 in the SEG motif has been reported (2,3). With limited information about its upstream kinases and downstream substrates, the significance of this phosphorylation remains to be elucidated (3,4). Erk3 is an inherently unstable protein, rapidly degraded through amino-terminal ubiquitination and proteasome degradation (3,5). A site-specific cleavage, depending on a short stretch of acidic residues of Erk3, might regulate its translocation from the Golgi/ERGIC to the nucleus during the cell cycle (6). Accumulating evidence suggests that Erk3 is involved in cell differentiation (1,3,6).
Reactivity Human, Mouse, Rat
Tested applications WB
Clonality Polyclonal Antibody
Calculated MW 83 kDa
Recommended Dilutions
WB 1:500-1:2000
Immunogen Synthetic Peptide of human Phospho-ERK3-S189
Storage Store at -20°C (regular) or -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Synonym ERK3, PRKM6, p97MAPK, HsT17250
This product is for research use only, not for diagnostic or therapeutic use!

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