NCF4 Rabbit Polyclonal Antibody
No Size Price Availability  
ARP4689-01 50ul 1500.00 In Stock
ARP4689-01 100ul 2000.00 In Stock
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Source: Rabbit Gene Id: 4689
Isotype: IgG Swiss Prot: Q15080
purity: Affinity purification
Background:
The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Reactivity Human, Mouse, Rat
Tested applications WB IHC IF
Clonality Polyclonal Antibody
Calculated MW 39 kDa
Recommended Dilutions
WB 1:500-1:2000
IHC 1:50-1:200
IF 1:50-1:200
Immunogen Recombinant protein of human NCF4
Storage Store at -20°C (regular) or -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Synonym NCF, P40PHOX, SH3PXD4
This product is for research use only, not for diagnostic or therapeutic use!

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