HLA-DRB1 Rabbit Polyclonal Antibody
No Size Price Availability  
ARP3123-01 50ul 1500.00 In Stock
ARP3123-01 100ul 2000.00 In Stock
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Source: Rabbit Gene Id: 3123
Isotype: IgG Swiss Prot: P01911
purity: Affinity purification
Background:
HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogs DRB3, DRB4 and DRB5. DRB1 is present in all individuals. Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4 and DRB5. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.
Reactivity Human
Tested applications WB IHC IF
Clonality Polyclonal Antibody
Calculated MW 30 kDa
Recommended Dilutions
WB 1:500-1:2000
IHC 1:50-1:200
IF 1:50-1:100
Immunogen Recombinant protein of human HLA-DRB1
Storage Store at -20°C (regular) or -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Synonym SS1, DRB1, DRw10, HLA-DRB, HLA-DR1B
This product is for research use only, not for diagnostic or therapeutic use!

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