| No | Size | Price | Availability | |
| ARP1832-01 | 50ul | 1500.00 | In Stock |  |
| ARP1832-01 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 1832 |
| Isotype: | IgG | Swiss Prot: | P15924 |
| purity: | Affinity purification |
| Background: |
| Desmosomes are intercellular junctions that tightly link adjacent cells. Desmoplakin is an obligate component of functional desmosomes that anchors intermediate filaments to desmosomal plaques. The N-terminus of desmoplakin is required for localization to the desmosome and interacts with the N-terminal region of plakophilin 1 and plakoglobin. The C-terminus of desmoplakin binds with intermediate filaments. In the mid-region of desmoplakin, a coiled-coiled rod domain is responsible for homodimerization. Mutations in this gene are the cause of several cardiomyopathies and keratodermas as well as the autoimmune disease paraneoplastic pemphigus. |
| Reactivity | Human, Mouse |
| Tested applications | WB IHC |
| Clonality | Polyclonal Antibody |
| Calculated MW | 332 kDa |
| Recommended Dilutions |
WB 1:500-1:2000
IHC 1:50-1:200
|
| Immunogen | Synthetic Peptide of human DSP |
| Storage | Store at -20°C (regular) or -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Synonym | DP, DPI, DPII, DCWHKTA |
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