Source: | Rabbit | Gene Id: | 23090 |
Isotype: | IgG | Swiss Prot: | Q2M1K9 |
purity: | Purified by Protein A. |
Background: |
Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved in terminal olfactory receptor neurons differentiation; this interaction preventing EBF1 to bind DNA and activate olfactory-specific genes. Involved in olfactory neurogenesis by participating in a developmental switch that regulates the transition from differentiation to maturation in olfactory receptor neurons. Controls proliferation and differentiation of neural precursors in cerebellar vermis formation. |
Reactivity | Mouse, Rat |
Tested applications | WB IHC IF |
Clonality | Polyclonal Antibody |
Calculated MW | / |
Recommended Dilutions |
WB 1:100-1:1000
IHC 1:100-1:500
IF 1:50-1:200
|
Immunogen | KLH conjugated synthetic peptide derived from human ZNF423/OAZ |
Storage | Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at -20℃ for 12 months |
Synonym | OAZ, Roaz, hOAZ, Ebfaz, JBTS19, NPHP14, ZFP423, Zfp104, Zinc finger protein 423, Olf1/EBF-associated zinc finger protein, Smad- and Olf-interacting zinc finger protein, ZNF423, KIAA0760 |
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