Source: | Rabbit | Gene Id: | 137492 |
Isotype: | IgG | Swiss Prot: | Q8NEZ2 |
purity: | Affinity purification |
Background: |
This gene belongs to the VPS37 family, and encodes a component of the ESCRT-I (endosomal sorting complex required for transport I) protein complex, required for the sorting of ubiquitinated transmembrane proteins into internal vesicles of multivesicular bodies. Expression of this gene is downregulated in hepatocellular carcinoma, and mutations in this gene are associated with autosomal recessive spastic paraplegia-53. A related pseudogene has been identified on chromosome 5. Alternatively spliced transcript variants have been found for this gene. |
Reactivity | Human |
Tested applications | WB IHC IF |
Clonality | Polyclonal Antibody |
Calculated MW | 44 kDa |
Recommended Dilutions |
WB 1:500-1:2000
IHC 1:50-1:200
IF 1:50-1:100
|
Immunogen | Recombinant protein of human VPS37A |
Storage | Store at -20°C (regular) or -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Synonym | HCRP1, PQBP2, SPG53 |
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