| No | Size | Price | Availability | |
| ARP5563-01 | 50ul | 1500.00 | In Stock |  |
| ARP5563-01 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 5563 |
| Isotype: | IgG | Swiss Prot: | P54646 |
| purity: | Affinity purification |
| Background: |
| The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. |
| Reactivity | Human, Mouse |
| Tested applications | WB IHC IF |
| Clonality | Polyclonal Antibody |
| Calculated MW | 62 kDa |
| Recommended Dilutions |
WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
|
| Immunogen | Recombinant protein of human PRKAA2 |
| Storage | Store at -20℃ (regular) or -80℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Synonym | AMPK; AMPK2; PRKAA; AMPKa2 |
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