| No | Size | Price | Availability | |
| ARP85358-31 | 50ul | 1500.00 | In Stock |  |
| ARP85358-31 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 85358 |
| Isotype: | IgG | Swiss Prot: | Q9BYB0 |
| purity: | Affinity purification |
| Background: |
| This gene is a member of the Shank gene family. Shank proteins are multidomain scaffold proteins of the postsynaptic density that connect neurotransmitter receptors, ion channels, and other membrane proteins to the actin cytoskeleton and G-protein-coupled signaling pathways. Shank proteins also play a role in synapse formation and dendritic spine maturation. Mutations in this gene are a cause of autism spectrum disorder (ASD), which is characterized by impairments in social interaction and communication, and restricted behavioral patterns and interests. Mutations in this gene also cause schizophrenia type 15, and are a major causative factor in the neurological symptoms of 22q13.3 deletion syndrome, which is also known as Phelan-McDermid syndrome. Additional isoforms have been described for this gene but they have not yet been experimentally verified. |
| Reactivity | Human, Mouse, Rat, Dog, Pig, Cow, Horse |
| Tested applications | WB IHC ELISA IF ICC |
| Clonality | Polyclonal Antibody |
| Calculated MW | 186 kDa |
| Recommended Dilutions |
WB 1:100-1:500
IHC 1:100-1:500
IF 1:100-1:500
ICC 1:100-1:500
|
| Immunogen | A synthetic peptide derived from human SHANK3 |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | PSAP2, SCZD15, PROSAP2, SPANK-2, DEL22q13.3 |
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