FYB Rabbit Polyclonal Antibody
No Size Price Availability  
ARP2534-31 50ul 1500.00 In Stock
ARP2534-31 100ul 2000.00 In Stock
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Source: Rabbit Gene Id: 2533
Isotype: IgG Swiss Prot: O15117
purity: Affinity purification
Background:
Fyb (Fyn binding protein) and the anchoring proteins SKAP55 (src kinase-associated phosphoprotein) and SKAP55-R (SKAP55-related protein) associate with the tyrosine kinase p59fyn. SKAP55 and SKAP55-R bind to Fyb through their SH3 domains and function as substrates for p59Fyn in resting T cells (1–3). SKAP55 contains an amino-terminal pleckstrin homology domain and a carboxy-terminal SH3 domain binding motif of adjacent arginine and lysine residues followed by tandem tyrosines (i.e. RKxxYxxY). SKAP55-R, similar in overall structure to SKAP55, contains a coiled-coil N-terminal domain. SKAP55 associates with SLAP-130, another component of the Fyn complex, which plays a role in the regulation of signaling events initiated by lymphocyte antigen receptors leading up to T cell activation. The human Fyb gene maps to chromosome 5p13.1 and encodes a 783 amino acid protein.
Reactivity Chicken, Cow, Dog, Horse, Human, Mouse, Pig, Rat, Sheep
Tested applications WB IHC ELISA IF ICC
Clonality Polyclonal Antibody
Calculated MW 85 kDa
Recommended Dilutions
WB 1:100-1:500
IHC 1:100-1:500
IF 1:100-1:500
ICC 1:100-1:500
Immunogen A synthetic peptide derived from human FYB/ADAP
Storage Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles.
Synonym ADAP, PRO0823, SLAP130, SLAP-130
This product is for research use only, not for diagnostic or therapeutic use!

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