| No | Size | Price | Availability | |
| ARP839C-21 | 50ul | 1500.00 | In Stock |  |
| ARP839C-21 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 839 |
| Isotype: | / | Swiss Prot: | P55212 |
| purity: | Affinity purification |
| Background: |
| Caspase-6 (Mch2) is one of the major executioner caspases functioning in cellular apoptotic processes (1,2). Upon apoptotic stimulation, initiator caspases such as caspase-9 are cleaved and activated (3). The activated upstream caspases further process downstream executioner caspases, such as caspase-3 and caspase-6, by cleaving them into large and small subunits, thereby initiating a caspase cascade leading to apoptosis (4,5). One of the major targets for caspase-6 is the membrane associated protein lamin A (6). The cleavage of this protein causes cell membrane malfunction, membrane blebbing and eventual cell death. |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB |
| Clonality | Polyclonal Antibody |
| Calculated MW | 18 kDa |
| Recommended Dilutions |
WB 1:1000
|
| Immunogen | A synthetic peptide corresponding to the carboxy-terminal sequence of p18, the large subunit of rat caspase-6 |
| Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | MCH2, CASP6, Caspase-6 |
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