| No | Size | Price | Availability | |
| ARP37729C-21 | 50ul | 1500.00 | In Stock |  |
| ARP37729C-21 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 37729(Drosophila) |
| Isotype: | / | Swiss Prot: | O02002 |
| purity: | Affinity purification |
| Background: |
| Cell death in the fruit fly Drosophila melanogaster is regulated by many of the same stimuli as mammalian cell death (1). The Drosophila genome contains seven caspase genes; three encode initiator caspases, and four encode effector caspases (reviewed in (2)). The Drosophila effector caspase, death caspase-1 (Dcp-1), is a critical executioner of apoptosis. It is involved in the proteolytic cleavage of many key proteins, such as the nuclear enzyme poly (ADP-ribose) polymerase (PARP). The activation of Dcp-1 requires proteolytic processing of its inactive zymogen into active p22 and p13 fragments (3). Comparison of the in vivo activity between DrICE and Dcp-1 has shown that DrICE is a more effective inducer of apoptosis than Dcp-1, which instead plays a role in determining the rate of cell death (4). |
| Reactivity | D. melanogaster |
| Tested applications | WB IF |
| Clonality | Polyclonal Antibody |
| Calculated MW | 22 kDa |
| Recommended Dilutions |
WB 1:1000
IF 1:100
|
| Immunogen | A synthetic peptide corresponding to amino-terminal residues adjacent to Asp216 of Drosophila Dcp-1 protein |
| Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | / |
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