| No | Size | Price | Availability | |
| ARP840C-21 | 50ul | 1500.00 | In Stock |  |
| ARP840C-21 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 840 |
| Isotype: | / | Swiss Prot: | P55210 |
| purity: | Affinity purification |
| Background: |
| Caspase-7 (CMH-1, Mch3, ICE-LAP3) has been identified as a major contributor to the execution of apoptosis (1-4). Caspase-7, like caspase-3, is an effector caspase that is responsible for cleaving downstream substrates such as (ADP-ribose) polymerase and PARP (1,3). During apoptosis, caspase-7 is activated through proteolytic processsing by upstream caspases at Asp23, Asp198, and Asp206 to produce the mature subunits (1,3). Similar to caspase-2 and -3, caspase-7 preferentially cleaves substrates following the recognition sequence DEVD (5). |
| Reactivity | Human, Monkey, Mouse, Rat |
| Tested applications | WB IP |
| Clonality | Polyclonal Antibody |
| Calculated MW | 20 kDa |
| Recommended Dilutions |
WB 1:1000
|
| Immunogen | A synthetic peptide corresponding to amino-terminal residues surrounding Asp198 in human caspase-7 |
| Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | CMH-1, ICE-LAP3, MCH3, CASP7, Caspase-7 |
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