| No | Size | Price | Availability | |
| ARPF024P-31 | 50ul | 1500.00 | In Stock |  |
| ARPF024P-31 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 2308/2309 |
| Isotype: | / | Swiss Prot: | Q12778/O43524 |
| purity: | Affinity purification |
| Background: |
| The Forkhead family of transcription factors is involved in tumorigenesis of rhabdomyosarcoma and acute leukemias (1-3). Within the family, three members (FoxO1, FoxO4, and FoxO3a) have sequence similarity to the nematode orthologue DAF-16, which mediates signaling via a pathway involving IGFR1, PI3K, and Akt (4-6). Active forkhead members act as tumor suppressors by promoting cell cycle arrest and apoptosis. Increased expression of any FoxO member results in the activation of the cell cycle inhibitor p27 Kip1. Forkhead transcription factors also play a part in TGF-β-mediated upregulation of p21 Cip1, a process negatively regulated through PI3K (7). Increased proliferation results when forkhead transcription factors are inactivated through phosphorylation by Akt at Thr24, Ser256, and Ser319, which results in nuclear export and inhibition of transcription factor activity (8). Forkhead transcription factors can also be inhibited by the deacetylase sirtuin (SirT1) (9). |
| Reactivity | Human, Monkey, Mouse, Rat |
| Tested applications | WB IP |
| Clonality | Polyclonal Antibody |
| Calculated MW | 78 to 82, 95 kDa |
| Recommended Dilutions |
WB 1:1000
|
| Immunogen | A synthetic phosphopeptide corresponding to residues surrounding Thr28 of human Fox04 |
| Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | / |
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