| No | Size | Price | Availability | |
| ARP8498P-21 | 50ul | 1500.00 | In Stock |  |
| ARP8498P-21 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 8498 |
| Isotype: | / | Swiss Prot: | Q9H6Z4 |
| purity: | Affinity purification |
| Background: |
| RanBP3 was originally identified as RanGTP binding protein located in the nucleus and involved in the nuclear exporting process (1). It functions as a cofactor for CRM1 nuclear export by binding to CRM1, stabilizing the RanGTP-CRM1-cargo interaction and promoting complex association with nuclear pore proteins (2,3). In the absence of Ran-bound GTP, RanBP3 prevents binding of CRM1 complex to the nuclear pore complex. In addition to CRM1, RanBP3 also has been shown to bind to RanGEF-RCC1 and increase the guanine nucleotide exchange activity of RCC1 for RanGTP-CRM1-Cargo (1,4). In some cases, as with β-catenin and Smad2/3, RanBP3 binding may mediate the target protein nuclear export in a Ran-dependent, but CRM1-independent manner (5,6). RanBP3 is phosphorylated at Ser58 through the PI3K/Akt or ERK/RSK pathway. This phosphorylation is important for RanBP3 function in nuclear export, likely due to stimulation of RCC1 activity (7,8). |
| Reactivity | Human, Monkey |
| Tested applications | WB IP |
| Clonality | Polyclonal Antibody |
| Calculated MW | 70 kDa |
| Recommended Dilutions |
WB 1:1000
|
| Immunogen | A synthetic peptide corresponding to residues surrounding Ser58 of human RanBP3b protein |
| Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | DKFZp586I1520 |
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