| No | Size | Price | Availability | |
| ARP5925P-32 | 50ul | 1500.00 | In Stock |  |
| ARP5925P-32 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 5925 |
| Isotype: | / | Swiss Prot: | P06400 |
| purity: | Affinity purification |
| Background: |
| The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. |
| Reactivity | Human, Monkey, Rat |
| Tested applications | WB IHC IP |
| Clonality | Polyclonal Antibody |
| Calculated MW | 110 kDa |
| Recommended Dilutions |
WB 1:1000
IHC 1:300
|
| Immunogen | A synthetic phosphopeptide corresponding to residues around Ser807/811 of human Rb |
| Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | RB, pRb, OSRC, pp110, p105-Rb |
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