Phospho-PLN-Ser16/Thr17 Rabbit Polyclonal Antibody
| No |
Size |
Price |
Availability |
|
| ARP5350P-21 |
50ul |
1500.00 |
In Stock |
 |
| ARP5350P-21 |
100ul |
2000.00 |
In Stock |
|
| Source: |
Rabbit |
Gene Id: |
5350 |
| Isotype: |
/ |
Swiss Prot: |
P26678 |
| purity: |
Affinity purification |
| Background: |
| The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure. [provided by RefSeq |
| Reactivity |
Rat |
| Tested applications |
WB |
| Clonality |
Polyclonal Antibody |
| Calculated MW |
6 kDa (monomer); 12 kDa, 24 kDa (oligomers) |
| Recommended Dilutions |
WB 1:1000
|
| Immunogen |
A synthetic phosphopeptide corresponding to residues surrounding Ser16/Thr17 of human phospholamban protein |
| Storage |
Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym |
CMD1P, PLB |
This product is for research use only, not for diagnostic or therapeutic use！
