Source: | Rabbit | Gene Id: | 56852 |
Isotype: | / | Swiss Prot: | Q9NS91 |
purity: | Affinity purification |
Background: |
The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens. |
Reactivity | Human |
Tested applications | WB IP |
Clonality | Polyclonal Antibody |
Calculated MW | 80, 90 kDa |
Recommended Dilutions |
WB 1:1000
|
Immunogen | A synthetic peptide corresponding to residues surrounding Ser403 of human Rad18 protein |
Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
Synonym | RNF73 |
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