| No | Size | Price | Availability | |
| ARP84126P-21 | 50ul | 1500.00 | In Stock |  |
| ARP84126P-21 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 84126 |
| Isotype: | / | Swiss Prot: | Q8WXE1 |
| purity: | Affinity purification |
| Background: |
| In response to genomic stress, the ATR interacting protein (ATRIP) binds and is phosphorylated by the DNA damage-and checkpoint-activated kinase ATR (ataxia-telangiectasia mutated and rad3-related). Both ATR and ATRIP are integral for checkpoint signaling and are critical in the DNA repair response (1-3). Direct interaction between ATRIP and replication protein A (RPA) at RPA-coated, single-stranded DNA results in the recruitment of phosphorylated ATR/ATRIP to stalled replication forks and sites of DNA damage (3). ATR/ATRIP coordinate DNA repair and cell cycle progression in conjunction with key regulatory proteins, such as Rad17 and the 9-1-1 complex (4). ATR associated with ATRIP can also be stimulated by topoisomerase II binding protein (TOPBP1), suggesting that ATRIP may regulate both ATR localization and activity (5).Cyclin dependent kinase 2 (CDK2) may participate in the regulation of DNA damage response and cell cycle control through phosphorylation of ATRIP at Ser224 (6). |
| Reactivity | Human |
| Tested applications | WB |
| Clonality | Polyclonal Antibody |
| Calculated MW | 86 kDa |
| Recommended Dilutions |
WB 1:1000
|
| Immunogen | A synthetic phoshopeptide corresponding to residues surrounding Ser224 of the human ATRIP protein |
| Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | DKFZp762J2115, FLJ12343, MGC20625, MGC21482, MGC26740 |
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