| No | Size | Price | Availability | |
| ARP10603-21 | 50ul | 1500.00 | In Stock |  |
| ARP10603-21 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 10603 |
| Isotype: | / | Swiss Prot: | O14492 |
| purity: | Affinity purification |
| Background: |
| APS is an SH2 and PH domain-containing adaptor protein closely related to Lnk and SH2-B (1). APS was identified as a substrate for many receptor tyrosine kinases including TrkA, insulin receptor, c-Kit and PDGF receptor (2). Tyrosine phosphorylation of APS provides docking sites for downstrean signaling components, mediating diverse signaling pathways. APS plays quite different roles in RTK signaling. Overexpression of APS has been shown to inhibit PDGF-induced mitogenicity, which may result from APS/c-Cbl-mediated PDGF receptor degradation (3). However, APS promotes enhanced mitogenicity in response to insulin stimulation (4). The striking difference in APS-mediated signaling between the different RTKs could lie in the mode of interaction with the respective receptor. |
| Reactivity | Human, Mouse |
| Tested applications | WB IHC |
| Clonality | Polyclonal Antibody |
| Calculated MW | 90 to 95 kDa |
| Recommended Dilutions |
WB 1:1000
IHC 1:50
|
| Immunogen | A synthetic peptide corresponding to residues near the amino-terminus of human APS |
| Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | APS |
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