| No | Size | Price | Availability | |
| ARP1326-21 | 50ul | 1500.00 | In Stock |  |
| ARP1326-21 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 1326 |
| Isotype: | / | Swiss Prot: | P41279 |
| purity: | Affinity purification |
| Background: |
| Tpl2 (tumor progression locus 2), also known as COT (cancer osaka thyroid), is a serine/threonine kinase expressed primarily in hematopoietic tissues, lung and liver (1). Over-expression of Tpl2 potentiates MAP kinase pathways through MEK1 and SEK1, as well as through MKK6 and MEK5 (2,3). Tpl2 is also engaged in NF-κB activation through NF-κB inducing kinase (NIK), or by inducing phosphorylation and degradation of the NF-κB precusor, p105 NF-κB1 (4,5). Ser400 of Tpl2 is phosphorylated in an Akt-dependent manner. This phosphorylation is required for Tpl2-induced NF-κB-dependent transcription (6). Tpl2 also activates caspase-3 by promoting the assembly of a protein complex of Apaf1 (apoptotic protease-activating factor 1), caspase-9, Tpl2, adaptor protein Tvl1 and procaspase-3 (7). |
| Reactivity | Rat |
| Tested applications | WB |
| Clonality | Polyclonal Antibody |
| Calculated MW | 60, 62 kDa |
| Recommended Dilutions |
WB 1:1000
|
| Immunogen | A mixture synthetic phosphorylated peptides corresponding to residues surrounding Ser400 of human, mouse and rat Tpl2 |
| Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | COT, EST, ESTF, FLJ10486, TPL2, Tpl-2, c-COT |
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