| No | Size | Price | Availability | |
| ARP47P-21 | 50ul | 1500.00 | In Stock |  |
| ARP47P-21 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 47 |
| Isotype: | / | Swiss Prot: | P53396 |
| purity: | Affinity purification |
| Background: |
| ACLY(ATP-citrate synthase) is also named as ACL. It is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA. ACLY serves as not only a target in oxygenated cells for suppression of lipid synthesis and histone acetylation, but also as a susceptible target in hypoxic cells to restore inhibition of glycolysis. In nonsmall cell lung carcinoma and hepatocellular carcinoma ,ACLY is overexpressed compared with normal parenchyma suggesting that ACLY may represent a common target among highly malignant tumors(PMID:19795461). This protein has 2 isoforms produced by alternative splicing. This antibody is specific to ACLY. |
| Reactivity | Human, Mouse |
| Tested applications | WB IP |
| Clonality | Polyclonal Antibody |
| Calculated MW | 125 kDa |
| Recommended Dilutions |
WB 1:1000
|
| Immunogen | A synthetic phosphopeptide corresponding to residues surrounding Ser455 of human ATP-citrate lyase |
| Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | ACL, ATPCL, CLATP |
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