| No | Size | Price | Availability | |
| ARP5564P-21 | 50ul | 1500.00 | In Stock |  |
| ARP5564P-21 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 5564 |
| Isotype: | / | Swiss Prot: | Q9Y478 |
| purity: | Affinity purification |
| Background: |
| The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex. |
| Reactivity | Human, Monkey, Mouse, Rat |
| Tested applications | WB IP |
| Clonality | Polyclonal Antibody |
| Calculated MW | 38 kDa |
| Recommended Dilutions |
WB 1:1000
|
| Immunogen | A synthetic phosphopeptide corresponding to residues surrounding Ser108 of human AMPKβ1 |
| Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | AMPK, HAMPKb |
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