Phospho-HSP90AA1-Thr5/7 Rabbit Polyclonal Antibody
No Size Price Availability  
ARP3320P-21 50ul 1500.00 In Stock
ARP3320P-21 100ul 2000.00 In Stock
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Source: Rabbit Gene Id: 3320
Isotype: / Swiss Prot: P07900
purity: Affinity purification
Background:
HSP70 and HSP90 are molecular chaperones expressed constitutively under normal conditions to maintain protein homeostasis and are induced upon environmental stress (1). Both HSP70 and HSP90 are able to interact with unfolded proteins to prevent irreversible aggregation and catalyze the refolding of their substrates in an ATP- and co-chaperone-dependent manner (1). HSP70 has a broad range of substrates including newly synthesized and denatured proteins, while HSP90 tends to have a more limited subset of substrates, most of which are signaling molecules. HSP70 and HSP90 often function collaboratively in a multi-chaperone system, which requires a minimal set of co-chaperones: HSP40, Hop, and p23 (2,3). The co-chaperones either regulate the intrinsic ATPase activity of the chaperones or recruit chaperones to specific substrates or subcellular compartments (1,4). When the ubiquitin ligase CHIP associates with the HSP70/HSP90 complex as a cofactor, the unfolded substrates are subjected to degradation by the proteasome (4). The biological functions of HSP70/HSP90 extend beyond their chaperone activity. They are essential for the maturation and inactivation of nuclear hormones and other signaling molecules (1,3). They also play a role in vesicle formation and protein trafficking (2).
Reactivity Human, Monkey, Mouse, Rat
Tested applications WB
Clonality Polyclonal Antibody
Calculated MW 90 kDa
Recommended Dilutions
WB 1:1000
Immunogen A synthetic phosphopeptide corresponding to residues surrounding Thr5/7 of human HSP90α
Storage Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles.
Synonym HSP90AA1, FLJ31884, HSP86, HSP89A, HSP90A, HSP90N, HSPC1, HSPCA, HSPCAL1, HSPCAL4, HSPN, Hsp89, Hsp90, LAP2
This product is for research use only, not for diagnostic or therapeutic use!

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