| No | Size | Price | Availability | |
| ARP1641P-22 | 50ul | 1500.00 | In Stock |  |
| ARP1641P-22 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 1641 |
| Isotype: | / | Swiss Prot: | O43602 |
| purity: | Affinity purification |
| Background: |
| Mutations in Doublecortin cause Lissencephaly (smooth brain), a neuronal migration disorder characterized by epilepsy and mental retardation (1). Doublecortin is a microtubule associated protein that stabilizes and bundles microtubules. A conserved doublecortin domain mediates the interaction with microtubules, and interestingly most missense mutations cluster in this domain (2). Kinases JNK, CDK5 and PKA phosphorylate doublecortin. JNK phosphorylates Thr321, Thr331 and Ser334 while PKA phosphorylates Ser47 and CDK5 phosphorylates Ser297 (3-5). Phosphorylation of Ser297 lowers the affinity of doublecortin to microtubules. Furthermore, mutations of Ser297 result in migration defects (5).Doublecortin phosphorylated at Ser334 is enriched in growth cones and affects neurite outgrowth and neuronal migration (3). |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB IP IF |
| Clonality | Polyclonal Antibody |
| Calculated MW | 45 kDa |
| Recommended Dilutions |
WB 1:1000
IF 1:200
|
| Immunogen | A synthetic phosphopeptide corresponding to residues surrounding Ser334 of doublecortin |
| Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | DCX, DBCN, DC, LISX, SCLH, XLIS |
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