| No | Size | Price | Availability | |
| MRP19417-21 | 50ul | 1500.00 | In Stock |  |
| MRP19417-21 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 19417(Mouse) |
| Isotype: | / | Swiss Prot: | P27671 |
| purity: | Affinity purification |
| Background: |
| Ras activity is regulated by GAP (GTPase activating proteins) and GEFs (guanine nucleotide exchange factors). Ras-GRF1 (also known as CDC25Mm) is neuronal RasGEF and is regulated by heterotrimeric G proteins and calcium influx (1,2). Binding to calmodulin and phosphorylation stimulate Ras-GRF1 activity (1,2). Multiple PKA phosphorylation sites on Ras-GRF have been identified. Phosphorylation on the two major sites, Ser54 and Ser822, inhibits Ras-GRF activity (3). Carbachol (a muscarinic agonist)-induced phosphorylation on Ser916 is essential but not sufficient for maximal Ras-GRF activity (4). It has been reported that Ras-GRF1 also shows GEF activity toward Rac after phosphorylation by the tyrosine kinase Src (5). |
| Reactivity | Mouse |
| Tested applications | WB |
| Clonality | Polyclonal Antibody |
| Calculated MW | 155 kDa |
| Recommended Dilutions |
WB 1:1000
|
| Immunogen | A synthetic peptide corresponding to the amino-terminal residues of mouse Ras-GRF1 |
| Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | / |
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