| No | Size | Price | Availability | |
| ARPF054-21 | 50ul | 1500.00 | In Stock |  |
| ARPF054-21 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 4478/5962/7430 |
| Isotype: | / | Swiss Prot: | P26038/P35241/P15311 |
| purity: | Affinity purification |
| Background: |
| The ezrin, radixin, and moesin (ERM) proteins function as linkers between the plasma membrane and the actin cytoskeleton and are involved in cell adhesion, membrane ruffling, and microvilli formation (1). ERM proteins undergo intra or intermolecular interaction between their amino- and carboxy-terminal domains, existing as inactive cytosolic monomers or dimers (2). Phosphorylation at a carboxy-terminal threonine residue (Thr567 of ezrin, Thr564 of radixin, Thr558 of moesin) disrupts the amino- and carboxy-terminal association and may play a key role in regulating ERM protein conformation and function (3,4). Phosphorylation at Thr567 of ezrin is required for cytoskeletal rearrangements and oncogene-induced transformation (5). Ezrin is also phosphorylated at tyrosine residues upon growth factor stimulation. Phosphorylation of Tyr353 of ezrin transmits a survival signal during epithelial differentiation (6). |
| Reactivity | Bovine, Human, Monkey, Mouse, Rat |
| Tested applications | WB |
| Clonality | Polyclonal Antibody |
| Calculated MW | 75 kDa Moesin. 80 kDa Ezrin and Radixin. |
| Recommended Dilutions |
WB 1:1000
|
| Immunogen | A synthetic peptide corresponding to the residues surrounding Thr567 of human ezrin |
| Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | / |
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