| No | Size | Price | Availability | |
| ARP1500P-23 | 50ul | 1500.00 | In Stock |  |
| ARP1500P-23 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 1500 |
| Isotype: | / | Swiss Prot: | O60716 |
| purity: | Affinity purification |
| Background: |
| Catenin δ-1 (p120 catenin) has an amino-terminal coiled-coil domain followed by a regulatory domain containing multiple phosphorylation sites and a central Armadillo repeat domain of ten linked 42-amino acid repeats. The carboxy-terminal tail has no known function (1). Catenin δ-1 fulfills critical roles in the regulation of cell-cell adhesion as it regulates E-cadherin turnover at the cell surface to determine the level of E-cadherin available for cell-cell adhesion (2). Catenin δ-1 has both positive and negative effects on cadherin-mediated adhesion (3). Actin dynamics are also regulated by catenin δ-1, which modulates RhoA, Rac, and cdc42 proteins (1). Analogous to β-catenin, catenin δ-1 translocates to the nucleus, although its role at this location is unclear. Many studies show that catenin δ-1 is expressed irregularly or is absent in various types of tumor cells, suggesting that catenin δ-1 may function as a tumor suppressor (4).Catenin δ-1 is phosphorylated at multiple tyrosine sites along its sequence both in vivo and in vitro (5). High levels of catenin δ-1 phosphorylated at Tyr228 are commonly seen in several carcinoma cell lines. EGFR signaling induces catenin δ-1 phosphorylation at Tyr228, with the phosphorylated protein becoming localized at adherens junctions although phosphorylation is not essential in junction formation (6). |
| Reactivity | Human |
| Tested applications | WB IF |
| Clonality | Polyclonal Antibody |
| Calculated MW | 95, 100 kDa |
| Recommended Dilutions |
WB 1:1000
IF 1:100
|
| Immunogen | A synthetic phosphopeptides corresponding to residues surrounding Tyr228 of human/mouse catenin δ-1 |
| Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | CAS, CTNND, KIAA0384, P120CAS, P120CTN, p120 |
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