| No | Size | Price | Availability | |
| ARP545P-31 | 50ul | 1500.00 | In Stock |  |
| ARP545P-31 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 545 |
| Isotype: | / | Swiss Prot: | Q13535 |
| purity: | Affinity purification |
| Background: |
| Ataxia telangiectasia mutated kinase (ATM) and ataxia telangiectasia and Rad3-related kinase (ATR) are PI3 kinase-related kinase (PIKK) family members that phosphorylate multiple substrates on serine or threonine residues that are followed by a glutamine in response to DNA damage or replication blocks (1-3). Despite the essential role of ATR in cell cycle signaling and DNA repair processes, little is known about its activation. Phosphorylation of ATR at serine 428 in response to UV-induced DNA damage has been suggested as a means of activating ATR (4,5). Threonine 1989 was also recently identified as a potential marker of activated ATR (6,7). |
| Reactivity | Human, Monkey, Mouse, Rat |
| Tested applications | WB |
| Clonality | Polyclonal Antibody |
| Calculated MW | 300 kDa |
| Recommended Dilutions |
WB 1:1000
|
| Immunogen | A synthetic peptide corresponding to residues surrounding Ser428 of human ATR |
| Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | FRP1, MEC1, SCKL, SCKL1 |
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