| No | Size | Price | Availability | |
| ARPF039-21 | 50ul | 1500.00 | In Stock |  |
| ARPF039-21 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 5530/5532/5533 |
| Isotype: | / | Swiss Prot: | Q08209/P16298/P48454 |
| purity: | Affinity purification |
| Background: |
| Calcineurin, also known as protein phosphatase 2B (PP2B), is a calmodulin-dependent, calcium-activated, serine/threonine protein phosphatase composed of a catalytic subunit (calcineurin A) and a tightly bound regulatory subunit (calcineurin B) (1). Calcineurin A is highly homologous to protein phosphatases 1 and 2A. Calcineurin B, like calmodulin, contains four EF-hand, calcium-binding motifs.Calcineurin signaling has been implicated in a broad spectrum of cellular processes including cell-cycle regulation, stress response and apoptosis and is required for proper cardiovascular and skeletal muscle development (2,3). Calcineurin-mediated dephosphorylation of the nuclear factor of activated T cells (NFAT) transcription factor is essential for NFAT activation and nuclear translocation and early gene expression in T lymphocytes (2,3). Calcineurin is the target of the immunosuppressive drugs Cyclosporin A and FK506, both of which block the activation of quiescent T cells after T cell receptor engagement (2,3). Cyclosporin A and FK506 bind to the immunophilins, cyclophilin and FKBP respectively and the immunophilin-drug complex binds to calcineurin and blocks substrate binding. |
| Reactivity | Human, Monkey, Mouse, Rat |
| Tested applications | WB IP IF FC |
| Clonality | Polyclonal Antibody |
| Calculated MW | 59 kDa |
| Recommended Dilutions |
WB 1:1000
IF 1:50
FC 1:25
|
| Immunogen | A synthetic peptide corresponding to the carboxy-terminus of human Calcineurin A (alpha isoform) |
| Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | / |
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