| No | Size | Price | Availability | |
| ARPF048-21 | 50ul | 1500.00 | In Stock |  |
| ARPF048-21 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 677/55290 |
| Isotype: | / | Swiss Prot: | Q07352/Q9HAW0 |
| purity: | Affinity purification |
| Background: |
| Butyrate response factor 1 (BRF1; also known as EGF response factor 1 [ERF1], TIS11B, ZFP36L1) and butyrate response factor 2 (BRF2; also known as EGF response factor 2 [ERF2], TIS11D, ZFP36L2) both belong to the TIS11 family of CCCH zinc-finger proteins (1). This family of proteins, which also includes tristetraprolin (TTP), bind to AU-rich elements (ARE) found in the 3'-untranslated regions of mRNAs and promote de-adenylation and rapid degradation by the exosome (2,3). These proteins play a critical role in cell growth control by regulating the mRNA turnover of multiple cytokines, growth factors and cell cycle regulators, including GM-CSF, TNFα, IL-2, IL-3 and IL-6 (4,5). Deregulated ARE-mRNA stability can contribute to both inflammation and oncogenic transformation (6-8). Insulin-induced stabilization of ARE-containing transcripts is mediated by Akt/PKB phosphorylation of BRF1 at Ser92, which results in binding by 14-3-3 protein and inactivation of BRF1 (9). |
| Reactivity | Human, Monkey, Mouse, Rat |
| Tested applications | WB IF FC |
| Clonality | Polyclonal Antibody |
| Calculated MW | 40 to 50, 62 kDa |
| Recommended Dilutions |
WB 1:1000
IF 1:125
FC 1:100
|
| Immunogen | A synthetic peptide corresponding to the carboxy terminus of human BRF1 protein |
| Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | / |
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