| No | Size | Price | Availability | |
| MRP20296-21S | 50ul | 1500.00 | In Stock |  |
| MRP20296-21S | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 20296(Mouse) |
| Isotype: | / | Swiss Prot: | P10148 |
| purity: | Affinity purification |
| Background: |
| Monocyte chemotactic protein-1 (MCP-1), also known as CCL2, monocyte chemotactic activating factor (MCAF) or glioma-derived chemotactic factor-2 (GDCF-2), is the product of the human JE gene and a member of the family of C-C (or β) chemokines (1-4). The predicted molecular weight of MCP-1 protein is 11-13 kDa, but it may migrate at 20-30 kDa due to glycosylation. MCP-1 is secreted by a variety of cell types in response to pro-inflammatory stimuli and was originally described for its chemotactic activity on monocytes. This activity has led to studies demonstrating its role in diseases characterized by monocyte infiltrates such as psoriasis (5), rheumatoid arthritis (6) and atherosclerosis (7). MCP-1 may also contribute to tumor progression and angiogenesis (8). Signaling by MCP-1 is mediated by the G-protein coupled receptor CCR2 (9). |
| Reactivity | Mouse |
| Tested applications | WB |
| Clonality | Polyclonal Antibody |
| Calculated MW | 11-13, 20-30 kDa |
| Recommended Dilutions |
WB 1:1000
|
| Immunogen | A synthetic peptide corresponding to residues surrounding Cys75 of mouse MCP-1 |
| Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | JE, HC11, MCAF, MCP1, MCP-1, Scya2, Sigje, SMC-CF, AI323594 |
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