| No | Size | Price | Availability | |
| HRP9140-21S | 50ul | 1500.00 | In Stock |  |
| HRP9140-21S | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 9140 |
| Isotype: | / | Swiss Prot: | O94817 |
| purity: | Affinity purification |
| Background: |
| Autophagy is a catabolic process for the autophagosomic-lysosomal degradation of bulk cytoplasmic contents (1,2). Autophagy is generally activated by conditions of nutrient deprivation but has also been associated with a number of physiological processes including development, differentiation, neurodegeneration, infection, and cancer (3). The molecular machinery of autophagy was largely discovered in yeast and referred to as autophagy-related (Atg) genes. Formation of the autophagosome involves a ubiquitin-like conjugation system in which Atg12 is covalently bound to Atg5 and targeted to autophagosome vesicles (4-6). This conjugation reaction is mediated by the ubiquitin E1-like enzyme Atg7 and the E2-like enzyme Atg10 (7,8). |
| Reactivity | Human |
| Tested applications | IP IF |
| Clonality | Polyclonal Antibody |
| Calculated MW | 16, 55 kDa |
| Recommended Dilutions |
WB 1:1000
IF 1:100
|
| Immunogen | A synthetic peptide corresponding to residues near the amino terminus of human Atg12 |
| Storage | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | APG12, APG12L, FBR93, HAPG12 |
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