| No | Size | Price | Availability | |
| ARP2064-31 | 50ul | 1500.00 | In Stock |  |
| ARP2064-31 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 2064 |
| Isotype: | IgG | Swiss Prot: | P04626 |
| purity: | Affinity purification |
| Background: |
| This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq |
| Reactivity | Human |
| Tested applications | WB IHC ELISA IF ICC |
| Clonality | Polyclonal Antibody |
| Calculated MW | 185 kDa |
| Recommended Dilutions |
WB 1:100-1:500
IHC 1:100-1:500
IF 1:100-1:500
ICC 1:100-1:500
|
| Immunogen | A synthetic peptide derived from human HER2 |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | CD340, HER-2, HER-2/neu, HER2, NEU, NGL, TKR1 |
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