| No | Size | Price | Availability | |
| ARPM003P-11 | 50ul | 1500.00 | In Stock |  |
| ARPM003P-11 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | / |
| Isotype: | / | Swiss Prot: | / |
| purity: | Affinity purification |
| Background: |
| The 14-3-3 proteins are a highly conserved family of proteins involved in the regulation of cell survival, apoptosis, proliferation and checkpoint control (1-5). Biological regulation by 14-3-3 is mediated through phosphorylation-dependent protein-protein interactions (6). Two different phospho-Ser-containing motifs are found within nearly all known 14-3-3 binding proteins (7). Motif 1 (Arg/Lys and Ser at positions -3 and -2, phospho-Ser at position 0, and Pro at position +2) is found in critical regulatory proteins including Bad, cdc25C, FKHRL1, PKC and c-Raf (5,7). Phospho-(Ser) 14-3-3 Binding Motif Polyclonal and (4E2) Monoclonal Antibodies provide powerful tools for the discovery and characterization of potential 14-3-3 binding proteins containing this motif and for high throughput drug discovery. |
| Reactivity | Bovine, Chiken, Dog, Human, Mouse, Primates, Rat, Sheep, Xenopus, Zebrafish |
| Tested applications | WB |
| Clonality | Polyclonal Antibody |
| Calculated MW | 29 kDa |
| Recommended Dilutions |
WB 1:1000
|
| Immunogen | A synthetic phosphopeptide corresponding to residues surrounding S58 of rat 14-3-3 protein |
| Storage | Store at -20°C in 10 mM HEPES, 150 mM NaCl, pH 7.5 (50% glycerol, 10% BSA.Avoid freeze/thaw cycles. |
| Synonym | / |
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