| No | Size | Price | Availability | |
| ARP838-11 | 50ul | 1500.00 | In Stock |  |
| ARP838-11 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 838 |
| Isotype: | / | Swiss Prot: | P51878 |
| purity: | Affinity purification |
| Background: |
| This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein; this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq |
| Reactivity | Bovine, Hamster, Human, Monkey, Mouse, Rabbit, Rat |
| Tested applications | WB |
| Clonality | Polyclonal Antibody |
| Calculated MW | 32, 20 kDa |
| Recommended Dilutions |
WB 0.5-4 ug/mL
|
| Immunogen | A synthetic peptide corresponding to residues surrounding amino acids 162 of human CASP5 |
| Storage | Store at -20°C. For long term storage store at -80°C in PBS, pH 7.2 (30% glycerol, 0.5 mg/mL BSA, 0.01% thimerosal).Avoid freeze/thaw cycles. |
| Synonym | ICE(rel)III, ICEREL-III, ICH-3, MGC141966 |
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