| No | Size | Price | Availability | |
| ARP5361-11 | 50ul | 1500.00 | In Stock |  |
| ARP5361-11 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 5361 |
| Isotype: | / | Swiss Prot: | Q9UIW2 |
| purity: | Affinity purification |
| Background: |
| Class 3 secreted semaphorin (Sema3A) is a chemorepellent that acts upon a wide variety of axons. As such, it induces a dramatic redistribution and depolymerization of actin filaments that results in growth cone collapse. Plexins are single membrane-spanning signaling proteins encompassing Plexin A1, A2, A3, and A4. Plexins form a complex with neuropilin-1 and -2 and the cell adhesion protein L1 to form a functional semaphorin receptor (1,2). The GTPase Rnd1 binds to the cytoplasmic domain of Plexin A1 to trigger cytoskeletal collapse. In contrast, the GTPase RhoD blocks Rnd1-mediated Plexin A1 activation and repulsion of sympathetic axons by Sema3A (3). |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB ELISA IP ICC |
| Clonality | Polyclonal Antibody |
| Calculated MW | 211 kDa |
| Recommended Dilutions |
WB 1:1000
IHC 1:100
|
| Immunogen | A synthetic peptide corresponding to N-terminus half of semaphorin domain in human PLXNA1 |
| Storage | Store at -20°C in PBS (without Mg2+ and Ca2+), 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide).Avoid freeze/thaw cycles. |
| Synonym | NOV, NOVP, PLEXIN-A1, PLXN1 |
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