| No | Size | Price | Availability | |
| ARP613-11 | 50ul | 1500.00 | In Stock |  |
| ARP613-11 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 613 |
| Isotype: | / | Swiss Prot: | P11274 |
| purity: | Affinity purification |
| Background: |
| A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq |
| Reactivity | Human, Mouse |
| Tested applications | WB |
| Clonality | Polyclonal Antibody |
| Calculated MW | 130,160,210 kDaa |
| Recommended Dilutions |
WB 1:500-1:1000
|
| Immunogen | A synthetic peptide corresponding to residues surrounding Y177 of human BCR |
| Storage | Store at -20°C in PBS, 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide).Avoid freeze/thaw cycles. |
| Synonym | ALL, BCR-ABL1, BCR1, CML, D22S11, D22S662, FLJ16453, PHL |
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