| Source: | Rabbit | Gene Id: | 640 |
| Isotype: | / | Swiss Prot: | P51451 |
| purity: | Protein G purification |
| Background: |
| Blk is a Src family protein tyrosine kinase expressed in all stages of B cell development (1,2). Activation of B cells by various ligands is accompanied by activation of Blk (3). It has been suggested that Blk is involved in the control of B cell differentiation and proliferation (4,5). Blk transcripts have also been detected in human thymocytes, but not in mature T cells, implicating that Blk may play an important role in thymopoiesis (6). Blk function may be redundant, however, as mice that do not express Blk are not impaired with respect to B cell development and immune response (7). |
| Reactivity | Human, Mouse |
| Tested applications | WB IHC ELISA |
| Clonality | Polyclonal Antibody |
| Calculated MW | 55 kDa |
| Recommended Dilutions |
WB 1:100-1:500
IHC 1:50-1:100
|
| Immunogen | A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human BLK |
| Storage | Store at 4°C. For long term storage store at -20°C in PBS (0.09% sodium azide).Avoid freeze/thaw cycles. |
| Synonym | MGC10442 |
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