| No | Size | Price | Availability | |
| ARP8394-11 | 50ul | 1500.00 | In Stock |  |
| ARP8394-11 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 8394 |
| Isotype: | / | Swiss Prot: | Q99755 |
| purity: | Protein G purification |
| Background: |
| Phosphatidylinositol-5-phosphate 4-kinases (PIP4K) synthesize phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2), a key precursor in phosphoinositide signaling that directly modulates the activity of signaling proteins and cellular processes. There are two subfamilies of PIP kinases, type I and II, that generate PtdIns(4,5)P2 from distinct substrate pools. PIP4 type I kinases use PtdIns5P as a substrate, whereas PIP5 type II kinases use PtdIns4P (1,2). In mammalian cells, three isoforms of each PIP4K and PIP5K subfamily, encoded by distinct genes, have been characterized (3-7). All PIP kinases are stimulated by phosphatidic acid, extensively regulated by ARF and Rho GTPases, and inhibited by protein kinase A and PI-stimulated autophosphorylation (8). |
| Reactivity | Human |
| Tested applications | WB ELISA |
| Clonality | Polyclonal Antibody |
| Calculated MW | 62 kDa |
| Recommended Dilutions |
WB 1:100-1:500
|
| Immunogen | A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human PIP5K1A |
| Storage | Store at 4°C. For long term storage store at -20°C in PBS (0.09% sodium azide).Avoid freeze/thaw cycles. |
| Synonym | / |
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